James Simpson
James, Jim, or Jimmy Simpson may refer to:
- James Simpson (explorer) (1911–2002), polar explorer
- James Young Simpson (1811–1870), Scottish doctor and pioneer in use of chloroform as anaesthetic
- James Young Simpson (scientist) (1873-1934), Scottish professor of natural science and a diplomat; great nephew of the above
- James Simpson (politician) (1873–1938), Canadian trade unionist and mayor of Toronto, 1935
- Jim Simpson (Australian politician) (1905–1968), member of the New South Wales Legislative Assembly
- James Simpson (civil servant) (c.1792–1857), early Australian civil servant and property developer
- James H. Simpson (1813–1883), surveyor of the American West for the U.S. Army.
- James Simpson (government official), New Jersey Department of Transportation commissioner and former Federal Transit Administrator for the United States DOT
- James Simpson, Jr. (1905–1960), U.S. Representative from Illinois
- James Simpson (engineer) (1799–1869), president of the Institution of Civil Engineers, 1853–1855
- James Simpson (composer), music theatre composer, performer and musical director, co-writer of Give My Regards to Broady
- Jim Simpson (director) (born 1956), American theatre and film director
- Jim Simpson (sportscaster) (born 1927), American sportscaster
- Jim Simpson (footballer), English footballer
- Jimmy Simpson (1908–1972), Scottish footballer
- William James Simpson, commonly known as James Simpson, academic